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Autoimmune disorders encompass a wide range of immunological diseases that affect 4 to 10% of the population worldwide. They occur when immunological tolerance toward self-antigens is broken, resulting in immune responses against cells, tissues, or organs that lead to tissue dysfunction and/or destruction. The goal of autoimmune disease therapy is to restore tolerance to the self-antigen that causes the pathology by targeting autoreactive T cells while preserving immune competence to prevent infections and malignancies. The main challenge of this endeavor resides in choosing the mode by which the disease-driving antigen is delivered so that it can initiate the removal or reprogramming of the autoreactive T cells or the induction and/or expansion of antigen-specific regulatory T (Treg) cells to suppress autoreactive T cells. Although the potential of antigenbased immunotherapy approaches to restore tolerance have been demonstrated for the treatment of immunoglobulin E (IgE) – mediated peanut allergy (1), antigen therapies for autoimmune disorders are still being developed.

War is raging in Ukraine and Gaza. The United States is headed for another tight, and heated, presidential election. Political upheaval is taking place in countries around the globe. And journalists are tasked with covering it all, despite the rise in threats to their physical and digital security, which are often connected.