Researchers at the University of Brasilia have discovered that the toxin from a tiny toad, native to Brazil’s Atlantic Forest might hold potential for vascular disease treatment.
The researchers said the toxins might lead to prevention and treatment of vascular diseases such as high blood pressure, endothelial dysfunction, and strokes.
This was reported by Metropoles, a partner of TV BRICS.
The specie, Brachycephalus ephippium, is notable for its bright orange or yellow colouring and small size, ranging from just 1.25 to 1.97 cm.
Brachycephalus ephippium is usually found abundantly in the Serra do Mar and Mantiqueira regions and the toad carries a peptide with significant cardiovascular potential.
The particular substance was first identified in 2015 during a scientific expedition.
Early studies showed that the compound’s vascular effects were similar to those of existing anti-hypertensive drugs.
In the most recent study, the toxin was tested on rats and found to promote blood vessel relaxation in mesenteric arteries, which supply vital nutrients and oxygen to organs.
The compound works by interacting with the enzyme argininosuccinate synthase, which plays a key role in producing nitric oxide: a molecule essential for vascular dilation.
According to project coordinator Professor Jose Roberto Leite, the new findings revealed further vascular benefits, including endothelial protection, increasing the compound’s potential as a preventative treatment for conditions like stroke.
The next stage involves clinical trials on humans to test the treatment’s safety and efficacy.
TV BRICS/NAN
