Fear, trust, and the likelihood of exposure are three leading factors that influence whether people are willing to be vaccinated against a virulent disease, according to a new study in the journal Heliyon, published by Elsevier.

Following the highly-publicized 2014 outbreak of Ebola in Africa and anticipating the possibility of a future Ebola outbreak in the United States, a 2014 CNN/ORC poll asked a random sample of 1,018 adults if they would take an anti-Ebola vaccination if and when it became available. About half of the participants reported that they would, while half expressed hesitation or refusal, even if vaccination services for Ebola were available to them.

In the current study, investigators conducted a secondary analysis of that data to examine the factors contributing to vaccination receptivity vs. hesitation. They found that three factors primarily influenced receptivity: a general fear orientation; trust in government to contain a crisis; and the relative chance of being exposed to the pathogen. Interestingly, the effectiveness and safety of a vaccine itself was not among the factors influencing receptivity.

• General Fear Orientation. Respondents expressed fear not only of being infected, but also more generally in terms of their outlook on life and how they perceive things are going overall in society today. The more than 60 percent who reported being somewhat or very scared about events in the US today were much more willing to consider an anti-Ebola vaccination than individuals who did not report this anxiety.
• Trust in Government. People who expressed confidence in the US government’s ability to prevent an Ebola outbreak were much more willing to take the anti-Ebola vaccine than individuals who lacked confidence in the government to do so.
• Exposure Expectancy of an Ebola Outbreak. Whileapproximately 80 percent of the respondents thought that it wassomewhator highly likely that an Ebola outbreak would happen fairly soon in the US, most people thought that the outbreak would not happen in their local community or family. However, the closer in proximity they thought the outbreak would be to them, the more willing they were to take the anti-Ebola vaccination.

Gustavo S. Mesch, PhD, Professor of Sociology and Rector, University of Haifa, Israel, the study’s other investigator, recommends reexamining the research questions with more current data. “Our life and death struggle against lethal microbes is ultimately fought at the local level. Unless local hospitals and health care personnel are prepared to fight and ready to go, we are at a major disadvantage in attempting to save lives,” he cautions.

Vaccination is the primary public health response to the growing number of infectious diseases that infect the world’s population. At the same time, a growing anti-vax movement has spawned a small but vocal faction of the population, spreading hesitancy despite widespread evidence of vaccine efficacy and safety. The reluctance or refusal to be vaccinated or to have one’s children vaccinated was identified by the World Health Organization as one of the top ten global health threats of 2019. Understanding the factors that contribute to vaccination compliance or hesitancy is vital for controlling disease outbreaks.

While currently Ebola is largely confined to Africa, other infectious diseases loom closer to the US, such as the measles outbreak in several US states. Against this backdrop, it is important to evaluate the public’s willingness to participate in preventive public health measures and understand what distinguishes those who are willing to partake from those who are not.